POS1337 BEHÇET`S DISEASE AND COURSE OF PREGNANCY - RESULTS FROM THE NATIONWIDE PREGNANCY REGISTER REVNATUS

Background: Behçets disease (BD) is a complex and multisystemic disorder of unknown etiology. It characterized by recurrent oral genital ulcers inflammatory eye involvement. can also affect the cardiovascular, pulmonary skeletal system. BD commonly diagnosed in women reproductive age. Pregnancy outcomes are reported previous studies with discrepancies rate pregnancy-related complications. Objectives: To describe course pregnancy patients BD. Methods: We prospectively collected data on outcome through nationwide Norwegian registry rheumatic diseases (RevNatus) from 2016-2020. All were ICD-10 code M35.2. 13 pregnancies 11 recorded. One had two including one twin birth. Results: Median age at conception was 30 years (range 25-32), median duration 7 1-15). There no serious organ manifestations. Tnf-alpha-inhibitors used 2 nd trimester 3 pregnancies. resulted live births gestational delivery 38 weeks 36-41). No preeclampsia or HELLP Table 1. Patient # Medication 2.nd Oral during Disease activity CRP value 2nd Gestational delivery, week Mode Birth weight, gram A 1 Azathioprine Colchicine LMWH persistent* SVD 3475 B Adalimumab LDPrednisolon yes persistent * 4 40 3215 C 5 41 3355 D 23 36 1940 E Etanercept ASA 3410 6a (twin) 37 Elective Sectio 2400 6b 2410 F flare** 15 3180 8 Acute 3049 G 9 remission*** 3150 H 10 2480 I 39 J 12 3115 K Ciklosporine 3130 = spontaneous vaginal acetylsalicylic acid, Low dose Prednisolon <10 mg/day, *= throughout pregnancy, **= flare once ***= remission Conclusion: Pregnancies this cohort uncomplicated. did not reveal any events, they all births. However, very heterogeneous disease, our have Larger cohorts representing heterogeneity needed to study Disclosure Interests: None declared